SubtiBank SubtiBank
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2017-08-02 09:11:262025-01-16 13:40:07

description

AAA ATPase, replication initiation protein

AAA ATPase, [[category|DNA replication|replication]] initiation protein

locus

BSU00010

BSU_00010

function

DNA replication

[[category|DNA replication]]

names

dnaA

dnaH

dnaJ

dnaK

dnaA

outlinks

bsu

BSU00010

BSU_00010

The protein

Protein family

dnaA family (according to Swiss-Prot)

DnaA family (single member, according to UniProt)

The protein

Effectors of protein activity

[[protein|SirA]] displaces [[protein|DnaA]] from the replication origin [Pubmed|19682252]

[[protein|YabA]] inhibits co-operative binding of DnaA to the ''oriC'' DNA [Pubmed|21895792]

DnaA helix formation (and thus replication initiation) is inhibited by the interaction of either [[protein|ParA]], [[protein|YabA]] or [[protein|DnaN]] with the AAA domain of DnaA [Pubmed|23909787,22286949]

interaction with [[protein|DnaD]] inhibits the ability of [[protein|DnaA]] to cooperatively bind to DNA [Pubmed|22821970]

[[protein|SirA]] displaces [[protein|DnaA]] from the replication origin [Pubmed|19682252]

[[protein|YabA]] inhibits co-operative binding of DnaA to the ''oriC'' DNA [Pubmed|21895792]

DnaA helix formation (and thus replication initiation) is inhibited by the interaction of either [[protein|ParA]], [[protein|YabA]] or [[protein|DnaN]] with the AAA domain of DnaA [Pubmed|23909787,22286949]

interaction with [[protein|DnaD]] inhibits the ability of [[protein|DnaA]] to cooperatively bind to DNA [Pubmed|22821970]

DNA gyrase ([[protein|GyrA]]-[[protein|GyrB]]) inhibits association of DnaA with [[gene|oriC]] [pubmed|29396913]

The protein

[SW|Localization]

throughout the cytoplasm [Pubmed|10844689]

throughout the cytoplasm [Pubmed|10844689]

co-localizes with the origin region and replication forks throughout the cell cycle [pubmed|28166228]

Labs working on this gene/protein

[SW|Peter Graumann], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]

[SW|Alan Grossman], MIT, Cambridge, MA, USA

[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]

References

Reviews

20157337, 21035377, 21639790, 22575476, 22797751, 26706151, 28075389

20157337, 21035377, 21639790, 22575476, 22797751, 26706151, 28075389, 30863373

References

Original publications

20511500, 21097613, 21239581, 21895792, 22286949, 22821970, 23909787, 22396664, 21911367, 25041308, 25340815, 26020636, 18854156, 19011033, 11222620, 14651647, 17140409, 10844689, 11222620, 12060778, 16461910, 2987848, 11207367, 19737352, 19081080, 17932079, 19968790, 19682252, 18216012, 2168872, 26615189, 27120414, 27489185, 27902860, 28166228

20511500, 21097613, 21239581, 21895792, 22286949, 22821970, 23909787, 22396664, 21911367, 25041308, 25340815, 26020636, 18854156, 19011033, 11222620, 14651647, 17140409, 10844689, 11222620, 12060778, 16461910, 2987848, 11207367, 19737352, 19081080, 17932079, 19968790, 19682252, 18216012, 2168872, 26615189, 27120414, 27489185, 27902860, 28166228, 28752667, 29396913, 30285297, 30534966, 31267560

The protein

Paralogous protein(s)

[[this]]

labs

[SW|Peter Graumann], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]

[SW|Alan Grossman], MIT, Cambridge, MA, USA

[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]