2017-08-02 09:11:262025-01-16 13:40:07
description
AAA ATPase, replication initiation protein
AAA ATPase, [[category|DNA replication|replication]] initiation protein
locus
BSU00010
BSU_00010
function
DNA replication
[[category|DNA replication]]
names
dnaA
dnaH
dnaJ
dnaK
dnaA
outlinks
bsu
BSU00010
BSU_00010
The protein
Protein family
dnaA family (according to Swiss-Prot)
DnaA family (single member, according to UniProt)
The protein
Effectors of protein activity
[[protein|SirA]] displaces [[protein|DnaA]] from the replication origin [Pubmed|19682252]
[[protein|YabA]] inhibits co-operative binding of DnaA to the ''oriC'' DNA [Pubmed|21895792]
DnaA helix formation (and thus replication initiation) is inhibited by the interaction of either [[protein|ParA]], [[protein|YabA]] or [[protein|DnaN]] with the AAA domain of DnaA [Pubmed|23909787,22286949]
interaction with [[protein|DnaD]] inhibits the ability of [[protein|DnaA]] to cooperatively bind to DNA [Pubmed|22821970]
[[protein|SirA]] displaces [[protein|DnaA]] from the replication origin [Pubmed|19682252]
[[protein|YabA]] inhibits co-operative binding of DnaA to the ''oriC'' DNA [Pubmed|21895792]
DnaA helix formation (and thus replication initiation) is inhibited by the interaction of either [[protein|ParA]], [[protein|YabA]] or [[protein|DnaN]] with the AAA domain of DnaA [Pubmed|23909787,22286949]
interaction with [[protein|DnaD]] inhibits the ability of [[protein|DnaA]] to cooperatively bind to DNA [Pubmed|22821970]
DNA gyrase ([[protein|GyrA]]-[[protein|GyrB]]) inhibits association of DnaA with [[gene|oriC]] [pubmed|29396913]
The protein
[SW|Localization]
throughout the cytoplasm [Pubmed|10844689]
throughout the cytoplasm [Pubmed|10844689]
co-localizes with the origin region and replication forks throughout the cell cycle [pubmed|28166228]
Labs working on this gene/protein
[SW|Peter Graumann], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]
[SW|Alan Grossman], MIT, Cambridge, MA, USA
[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]
References
Reviews
References
Original publications
The protein
Paralogous protein(s)
[[this]]
labs
[SW|Peter Graumann], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]
[SW|Alan Grossman], MIT, Cambridge, MA, USA
[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]